Sleep Relief
A breakthrough in sleep technology™
Poor sleep increases your risk for diabetes, heart disease, high blood pressure and death. It also makes you tired, irritable, depressed and less productive. You can’t afford another poor night’s sleep. Sleep Relief can help.
Sleep Relief’s biphasic, time-release technology releases clinically tested nutrients formula in two stages. The quick-release first stage helps you gently fall asleep. The slow-release second stage helps you stay asleep and wake refreshed and ready for your day.
Bi-phasic, time-release technology.
Proprietary formula promotes healthy, restful sleep.
Helps you wake refreshed and ready for your day.
Gentle. Natural.
Bi-phasic, time-release technology.
Proprietary formula promotes healthy, restful sleep.
Helps you wake refreshed and ready for your day.
Gentle. Natural.
Special Report: Dr. Neustadt’s Ultimate Sleep Guide
Why You Can’t Sleep and What to Do About It
Nearly everyone experiences some sleep problems during their life, and most folks are chronically sleep deprived. There are a lot causes for poor sleep, including medications, using technology at night, anxiety, poor blood sugar control and nutritional deficiencies. Fortunately, natural, integrative approaches have been shown to improve sleep. Dr. Neustadt’s article helps you navigate the research and your choices to help you start getting consistently great sleep. Your busy life demands a good night’s sleep. Learn what you can to do to get a better night’s sleep.
Sleep Relief Results
The Sleep Relief Difference
*Footnotes
*With bi-phasic technology nutrients are released in two stages. During Stage 1, nutrients are released within 30-60 minutes to help you fall asleep. During Stage 2, nutrients are released over the next 4-5 hours to promote healthy restful sleep all night long.
**Adaptogenic herbs are plants that work with your body to help it adapt to stress. Adaptogens are a natural ally in dealing with stress and fatigue. To qualify as an adaptogen it must have broad uses for health, and it must specifically reduce both mental and physical stress. For centuries cultures around the world have used adaptogenic herbs and modern science has proven their powerful health benefits, including for supporting a healthy sleep cycle.
†Standardized extracts guarantee a uniform quality and consistency across manufacturing batches. They also are what are most commonly used in human clinical trials.
Sleep Relief Frequently Asked Questions
How to take Sleep Relief
Product formula and manufacturing
Product safety
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Research Citations for Ingredients in Sleep Relief
Ashwaghanda (Withania somnifera)
Dar NJ, Hamid A, Ahmad M. Pharmacologic overview of Withania somnifera, the Indian Ginseng. Cell Mol Life Sci. 2015;72(23):4445-4460. [Article]
Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140. [Article]
Kaushik MK, Kaul SC, Wadhwa R, Yanagisawa M, Urade Y. Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One. 2017;12(2):e0172508. [Article]
Kumar A, Kalonia H. Effect of Withania somnifera on Sleep-Wake Cycle in Sleep-Disturbed Rats: Possible GABAergic Mechanism. Indian J Pharm Sci. 2008;70(6):806-810. [Article]
Mishra L-C, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000;5(4):334-346. [Article]
Glycine
Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-148. [Article]
Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61. [Article]
Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol. 2006;147 Suppl 1:S109-119. [Article]
Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. [Article]
Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 2007;5(2):126-131. [Article]
Jujube (Ziziphus jujuba)
Chen J, Liu X, Li Z, et al. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. Evid Based Complement Alternat Med. 2017;vol. 2017:Article ID 3019568. [Article]
Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140. [Article]
Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124(3):421-425. [Article]
Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep. 2017;9:163-169. [Article]
Rodriguez Villanueva J, Rodriguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phytother Res. 2017;31(3):347-365. [Article]
Singh A, Zhao K. Treatment of Insomnia With Traditional Chinese Herbal Medicine. Int Rev Neurobiol. 2017;135:97-115. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]
L-Tryptophan
Demisch K, Bauer J, Georgi K, Demisch L. Treatment of severe chronic insomnia with L-tryptophan: results of a double-blind cross-over study. Pharmacopsychiatry. 1987;20(6):242-244. [Article]
Hartmann E, Spinweber CL. Sleep induced by L-tryptophan. Effect of dosages within the normal dietary intake. J Nerv Ment Dis. 1979;167(8):497-499. [Article]
Hudson C, Hudson SP, Hecht T, MacKenzie J. Protein source tryptophan versus pharmaceutical grade tryptophan as an efficacious treatment for chronic insomnia. Nutr Neurosci. 2005;8(2):121-127. [Article]
L-Tryptophan. Monograph. Altern Med Rev. 2006;11(1):52-56. [Article]
Schneider-Helmert D. Interval therapy with L-tryptophan in severe chronic insomniacs. A predictive laboratory study. Int Pharmacopsychiatry. 1981;16(3):162-173. [Article]
Spinweber CL. L-tryptophan administered to chronic sleep-onset insomniacs: late-appearing reduction of sleep latency. Psychopharmacology (Berl). 1986;90(2):151-155. [Article]
Magnolia (Magnolia officinalis)
Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology. 2012;63(6):1191-1199. [Artcle]
Hoffmann KM, Herbrechter R, Ziemba PM, et al. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Frontiers in Pharmacology. 2016;7(219). [Article]
Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124(3):421-425. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]
Woodbury A, Yu SP, Wei L, Garcia P. Neuro-modulating effects of honokiol: a review. Front Neurol. 2013;4:130. [Article]
Pine bark extract
Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med. 2013;58(1-2):39-46. [Article]
Li YY, Feng J, Zhang XL, Cui YY. Pine bark extracts: nutraceutical, pharmacological, and toxicological evaluation. J Pharmacol Exp Ther. 2015;353(1):9-16. [Article]
Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. 2002;40(4):158-168. [Article]
GABA
Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol. 2006;147 Suppl 1:S109-119. [Article]
Li J, Zhang Z, Liu X, et al. Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics. Front Pharmacol. 2015;6:260. [Article]
Luppi PH, Peyron C, Fort P. Not a single but multiple populations of GABAergic neurons control sleep. Sleep Med Rev. 2017;32:85-94. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. J Nutr Sci Vitaminol (Tokyo). 2015;61(2):182-187. [Article]
Hops (Humulus lupulus)
Blumenthal M, Busse W. The Complete German Commission E Monographs. Austin, TX: American Botanical Council; 1998. [Book]
Franco L, Sanchez C, Bravo R, Rodriguez A, Barriga C, Juanez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012;99(2):133-139. [Article]
Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep. 2017;9:163-169. [Article]
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]
L-Theanine
Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-354. [Article]
Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-168. [Article]
Turkozu D, Sanlier N. L-theanine, unique amino acid of tea, and its metabolism, health effects, and safety. Crit Rev Food Sci Nutr. 2017;57(8):1681-1687. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Magnesium
Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169. [Article]
DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. [Article]
Hornyak M, Voderholzer U, Hohagen F, Berger M, Riemann D. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998;21(5):501-505. [Article]
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(Suppl 1):i3-i14. [Article]
Johnson S. The multifaceted and widespread pathology of magnesium deficiency. Med Hypotheses. 2001;56(2):163-170. [Article]
Melatonin
Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017;34:10-22. [Article]
Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013;8(5):e63773. [Article]
Gooneratne NS, Edwards AY, Zhou C, Cuellar N, Grandner MA, Barrett JS. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J Pineal Res. 2012;52(4):437-445. [Article]
Hardeland R. Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment. Aging Dis. 2012;3(2):194-225. [Article]
Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. 2007;16(4):372-380. [Article]
Lyseng-Williamson KA. Melatonin prolonged release: in the treatment of insomnia in patients aged >/=55 years. Drugs Aging. 2012;29(11):911-923. [Article]
Tordjman S, Chokron S, Delorme R, et al. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017;15(3):434-443. [Article]
Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007;23(10):2597-2605. [Article]
Skullcap (Scutellaria lateriflora)
Chang HH, Yi PL, Cheng CH, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 2011;135(2):359-368. [Article]
de Carvalho RS, Duarte FS, de Lima TC. Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behav Brain Res. 2011;221(1):75-82. [Article]
Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140. [Article]
Hoffmann KM, Herbrechter R, Ziemba PM, et al. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Frontiers in Pharmacology. 2016;7(219). [Article]
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860. [Article]
Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]
Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402.[Article]
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Disclaimer: These statements have not been evaluated by the FDA.
These products are not intended to diagnose, treat, cure, or prevent any disease.