Sleep Relief 

Nearly 70 million Americans can’t get a good night’s sleep. Poor sleep increases the risk for diabetes, heart disease, high blood pressure and death. Studies show sleep deprivation increases fatigue, irritability, depression and difficulty concentrating and performing everyday tasks. You can’t afford another poor night’s sleep.

Sleep Relief can help. Sleep Relief’s non-addictive, natural formula combines vitamins, magnesium, amino acids and plant extracts to target all phases of sleep. Sleep Relief’s time-release technology delivers clinically tested nutrients in two stages—a quick-release first stage and a slow-release second stage that provides the remaining nutrients during the night—to help you gently fall asleep, stay asleep and wake refreshed and ready for your day.

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Bi-phasic, time-release technology.

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Proprietary formula promotes healthy, restful sleep.

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Helps you wake refreshed and ready for your day.

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Gentle. Natural.

R

Bi-phasic, time-release technology.

R

Proprietary formula promotes healthy, restful sleep.

R

Helps you wake refreshed and ready for your day.

R

Gentle. Natural.

Why You Can’t Sleep and What to Do About It

Nearly everyone experiences some sleep problems during their life, and most folks are chronically sleep deprived. There are a lot causes for poor sleep, including medications, using technology at night, anxiety, poor blood sugar control and nutritional deficiencies. Fortunately, natural, integrative approaches have been shown to improve sleep. Dr. Neustadt’s article helps you navigate the research and your choices to help you start getting consistently great sleep. Your busy life demands a good night’s sleep. Learn what you can to do to get a better night’s sleep.

Sleep Relief Results

The Sleep Relief Difference

*Footnotes

*With bi-phasic technology nutrients are released in two stages. During Stage 1, nutrients are released within 30-60 minutes to help you fall asleep. During Stage 2, nutrients are released over the next 4-5 hours to promote healthy restful sleep all night long.

**Adaptogenic herbs are plants that work with your body to help it adapt to stress. Adaptogens are a natural ally in dealing with stress and fatigue. To qualify as an adaptogen it must have broad uses for health, and it must specifically reduce both mental and physical stress. For centuries cultures around the world have used adaptogenic herbs and modern science has proven their powerful health benefits, including for supporting a healthy sleep cycle.

†Standardized extracts guarantee a uniform quality and consistency across manufacturing batches. They also are what are most commonly used in human clinical trials.

Sleep Relief Frequently Asked Questions

How to take Sleep Relief
Q: Can I take Sleep Relief if I am taking sleep medications?

A: Do not take sleep relief if you are taking medications that cause drowsiness. If you are taking medications or have any medical conditions, check with your healthcare provider before taking Sleep Relief.

Q: How long before I go to bed should I take it?

A: For a great night’s sleep, take Sleep Relief 30-45 minutes before bed. Sweet dreams.

Q: How many tablets should I take to help me sleep?

A: The recommendation on the Sleep Relief product is for people to take 1-2 tablets. We recommend you start with 1 tablet for a few nights and see how you feel. If you want to try more, then you can take 2 tablets at bedtime. The correct number of tablets will be whatever will help you fall asleep, stay asleep and wake refreshed in the morning.

Q: Will Sleep Relief leave me feeling groggy in the morning?

A: Sleep Relief’s non-groggy formula should not create that feeling of sluggishness or fogginess in the morning.

Product formula and manufacturing
Q: Why does Sleep Relief come as a biphasic, time-release tablet?

A: Sleep Relief’s delivery system ensures your body is getting the right nutrients during the night to target various physiological influences on sleep.

Q: Why are there adaptogenic herbs in Sleep Relief?

A: Adaptogenic herbs such as Ashwaghanda and Jujube help the body react to stress and blunt the response to the stress hormone cortisol. They have calming effects and have been used in traditional cultures around the world to promote healthy sleep.

Q: How much melatonin is in Sleep Relief?

A: Sleep Relief contains just 1 mg melatonin per tablet. The body produces only a very small amount of melatonin, and most melatonin products on the market contain more than what is needed for healthy sleep. Additionally, melatonin is eliminated by the body very quickly. That is why Sleep Relief’s bi-phasic, time release tablets are superior, because they provide a slow and steady release of melatonin for your body to use during the night.

Product safety
Q: Is Sleep Relief habit forming?

A: No. Sleep Relief’s natural formula provides nutrients to promote healthy sleep.

Q: Is it safe to take Sleep Relief with sleep medications or other sleep aids?

A: No. Do not take Sleep Relief if you are taking medications that cause drowsiness.

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Research Citations for Ingredients in Sleep Relief

Ashwaghanda (Withania somnifera)

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Mishra L-C, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000;5(4):334-346. [Article]

Glycine

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Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012;3:61. [Article]

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Kawai N, Sakai N, Okuro M, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015;40(6):1405-1416. [Article]

Yamadera W, Inagawa K, Chiba S, Bannai M, Takahashi M, Nakayama K. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep and Biological Rhythms. 2007;5(2):126-131. [Article]

Jujube (Ziziphus jujuba)

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Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124(3):421-425. [Article]

Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep. 2017;9:163-169. [Article]

Rodriguez Villanueva J, Rodriguez Villanueva L. Experimental and Clinical Pharmacology of Ziziphus jujuba Mills. Phytother Res. 2017;31(3):347-365. [Article]

Singh A, Zhao K. Treatment of Insomnia With Traditional Chinese Herbal Medicine. Int Rev Neurobiol. 2017;135:97-115. [Article]

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Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]

L-Tryptophan

Demisch K, Bauer J, Georgi K, Demisch L. Treatment of severe chronic insomnia with L-tryptophan: results of a double-blind cross-over study. Pharmacopsychiatry. 1987;20(6):242-244. [Article]

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L-Tryptophan. Monograph. Altern Med Rev. 2006;11(1):52-56. [Article]

Schneider-Helmert D. Interval therapy with L-tryptophan in severe chronic insomniacs. A predictive laboratory study. Int Pharmacopsychiatry. 1981;16(3):162-173. [Article]

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Magnolia (Magnolia officinalis)

Chen CR, Zhou XZ, Luo YJ, Huang ZL, Urade Y, Qu WM. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, induces sleep via the benzodiazepine site of GABA(A) receptor in mice. Neuropharmacology. 2012;63(6):1191-1199. [Artcle]

Hoffmann KM, Herbrechter R, Ziemba PM, et al. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Frontiers in Pharmacology. 2016;7(219). [Article]

Koetter U, Barrett M, Lacher S, Abdelrahman A, Dolnick D. Interactions of Magnolia and Ziziphus extracts with selected central nervous system receptors. J Ethnopharmacol. 2009;124(3):421-425. [Article]

Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]

Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]

Woodbury A, Yu SP, Wei L, Garcia P. Neuro-modulating effects of honokiol: a review. Front Neurol. 2013;4:130. [Article]

Pine bark extract

Kohama T, Negami M. Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial. J Reprod Med. 2013;58(1-2):39-46. [Article]

Li YY, Feng J, Zhang XL, Cui YY. Pine bark extracts: nutraceutical, pharmacological, and toxicological evaluation. J Pharmacol Exp Ther. 2015;353(1):9-16. [Article]

Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther. 2002;40(4):158-168. [Article]

GABA

Bowery NG, Smart TG. GABA and glycine as neurotransmitters: a brief history. Br J Pharmacol. 2006;147 Suppl 1:S109-119. [Article]

Li J, Zhang Z, Liu X, et al. Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics. Front Pharmacol. 2015;6:260. [Article]

Luppi PH, Peyron C, Fort P. Not a single but multiple populations of GABAergic neurons control sleep. Sleep Med Rev. 2017;32:85-94. [Article]

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Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. J Nutr Sci Vitaminol (Tokyo). 2015;61(2):182-187. [Article]

Hops (Humulus lupulus)

Blumenthal M, Busse W. The Complete German Commission E Monographs. Austin, TX: American Botanical Council; 1998. [Book]

Franco L, Sanchez C, Bravo R, Rodriguez A, Barriga C, Juanez JC. The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. Acta Physiol Hung. 2012;99(2):133-139. [Article]

Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep. 2017;9:163-169. [Article]

Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860. [Article]

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Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402. [Article]

L-Theanine

Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-354. [Article]

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Magnesium

Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169. [Article]

DiNicolantonio JJ, O’Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart. 2018;5(1):e000668. [Article]

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Melatonin

Auld F, Maschauer EL, Morrison I, Skene DJ, Riha RL. Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders. Sleep Med Rev. 2017;34:10-22. [Article]

Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013;8(5):e63773. [Article]

Gooneratne NS, Edwards AY, Zhou C, Cuellar N, Grandner MA, Barrett JS. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J Pineal Res. 2012;52(4):437-445. [Article]

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Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res. 2007;16(4):372-380. [Article]

Lyseng-Williamson KA. Melatonin prolonged release: in the treatment of insomnia in patients aged >/=55 years. Drugs Aging. 2012;29(11):911-923. [Article]

Tordjman S, Chokron S, Delorme R, et al. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017;15(3):434-443. [Article]

Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007;23(10):2597-2605. [Article]

Skullcap (Scutellaria lateriflora)

Chang HH, Yi PL, Cheng CH, et al. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. J Ethnopharmacol. 2011;135(2):359-368. [Article]

de Carvalho RS, Duarte FS, de Lima TC. Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behav Brain Res. 2011;221(1):75-82. [Article]

Head KA, Kelly GS. Nutrients and botanicals for treatment of stress: adrenal fatigue, neurotransmitter imbalance, anxiety, and restless sleep. Altern Med Rev. 2009;14(2):114-140. [Article]

Hoffmann KM, Herbrechter R, Ziemba PM, et al. Kampo Medicine: Evaluation of the Pharmacological Activity of 121 Herbal Drugs on GABAA and 5-HT3A Receptors. Frontiers in Pharmacology. 2016;7(219). [Article]

Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011;21(12):841-860. [Article]

Weeks BS. Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action. Med Sci Monit. 2009;15(11):RA256-262. [Article]

Wing Y. Herbal treatment of insomnia. Hong Kong Medical Journal. 2001;7:392-402.[Article]

Vitamins B3 and B6

Lord R, Braley JA, eds. Laboratory Evaluations for Integrative and Functional Medicine. 2nd ed. Duluth: Metametrix Institute; 2008. [Book]

Peuhkuri K, Sihvola N, Korpela R. Dietary factors and fluctuating levels of melatonin. Food Nutr Res. 2012;56. [Article]

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