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Joint Relief 

Don’t let pain keep you watching from the sidelines. Backed by more than 25 studies, Joint Relief’s formula contains a combination of proteolytic enzymes, minerals and standardized plant extracts. Joint Relief’s nutrients attacks pain and inflammation at their source—at the cellular, molecular and genetic levels.

Joint Relief relieves pain and inflammation so you can get back to doing the activities you love.

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Promotes joint comfort

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Supports healthy joint mobility

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Promotes increased range of motion and pain-free activity

Joint Relief

Formulated by physicians from
Harvard, Cornell, MIT and Bastyr

Don’t let pain keep you watching from the sidelines. Backed by more than 25 studies, Joint Relief’s formula contains a combination of proteolytic enzymes, minerals and standardized plant extracts. Joint Relief’s nutrients attacks pain and inflammation at their source—at the cellular, molecular and genetic levels.

Joint Relief relieves pain and inflammation so you can get back to doing the activities you love.

R

Promotes joint comfort

R

Supports healthy joint mobility

R

Promotes increased range of motion and pain-free activity

Osteoarthritis: Heart Disease for Joints

Joint pain causes too many people to miss out on some of the greatest moments of their lives. While friends and family are enjoying themselves riding bikes, playing tennis, hiking, gardening, dancing or playing with their kids and grandkids, they’re sitting on the sidelines, unable to fully participate. And if they do, they’re often experiencing pain and discomfort, or paying for it later as their joint pain flares up.

Joint Relief Frequently Asked Questions

How to take Joint Relief for maximum benefit

Q: How many capsules do I take per day? A: The recommendation on the bottle suggests people take 3 capsules per day.

Q: How long will a bottle last? A: If you take the recommended 3 capsules per day, one bottle will last 30 days.

Q: Do I have to take all 3 capsules at the same time? A: No, although once-daily dosing will be more convenient for most people.

Q: Do I need to take the capsules with food? A: You don’t need to take the capsules with food. You can if you’d like, but it’s not required.

Q: If I can’t swallow pills, can I still take Joint Relief?  A: Yes. Simply open the capsules and mix with room temperature or colder food such as yogurt or cottage cheese.

How you’ll know if Joint Relief is helping you

Q: How will I know if Joint Relief is helping me? A: You should expect to feel better, with less discomfort and more joint mobility. Joint Relief is a dietary supplement with clinically validated nutrients to promote joint comfort and support joint health and healthy joint mobility. It’s nutrients have been shown in clinical trials to reduce joint swelling and pain and increase joint range of motion and pain-free activity.

Q: How long should it take until I should expect results? A: Clinical trials on the ingredients suggest that on average it can take 10-14 days to experience benefits; however, many volunteers in the studies got relief faster.

 

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Research Citations for Ingredients in Joint Relief

Ashwagandha (Withania somnifera)

Dragos D, Gilca M, Gaman L, et al. Phytomedicine in Joint Disorders. Nutrients. 2017;9(1). [Article]

Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33(1-2):91-95. [Article]

Ramakanth GS, Uday Kumar C, Kishan PV, Usharani P. A randomized, double blind placebo controlled study of efficacy and tolerability of Withania somnifera extracts in knee joint pain. J Ayurveda Integr Med. 2016;7(3):151-157. [Article]

Boron

Newnham RE. Essentiality of boron for healthy bones and joints. Environ Health Perspect. 1994;102 Suppl 7:83-85. [Article]

Pietrzkowski Z, Phelan MJ, Keller R, Shu C, Argumedo R, Reyes-Izquierdo T. Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. Clin Interv Aging. 2014;9:895-899. [Article]

Pizzorno L. Nothing Boring about Boron. Integrative Medicine 2015;14(4):35-48. [Article]

Reyes-Izquierdo T, Nemzer B, Gonzalez AE, et al. Short-term Intake of Calcium Fructoborate Improves WOMAC and McGill Scores and Beneficially Modulates Biomarkers Associated with Knee Osteoarthritis: A Pilot Clinical Double-blinded Placebo-controlled Study. Am J Biomed Sci. 2012;4(2):111-122. [Article]

Bromelain

Brien S, Lewith G, Walker A, Hicks SM, Middleton D. Bromelain as a Treatment for Osteoarthritis: a Review of Clinical Studies. Evid Based Complement Alternat Med. 2004;1(3):251-257. [Article]

Jayachandran S, Khobre P. Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis – A Randomised Clinical Trial. J Clin Diagn Res. 2017;11(6):ZC09-ZC11. [Article]

Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016;35(10):2531-2540. [Article]

Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30. [Article]

Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203. [Article]

Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002;9(8):681-686. [Article]

Boswellia serrata (Indian frankincense)

Dragos D, Gilca M, Gaman L, et al. Phytomedicine in Joint Disorders. Nutrients. 2017;9(1). [Article]

Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–A randomized double blind placebo controlled trial. Phytomedicine. 2003;10:3-7. [Article]

Kizhakkedath R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep. 2013;8(5):1542-1548. [Article]

Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33(1-2):91-95. [Article]

Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther. 1992;261(3):1143-1146. [Article]

Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377. [Article]

Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-622. [Article]

Magnesium

Na HS, Ryu JH, Do SH. The role of magnesium in pain. In: Vink R, Nechifor M, eds. Magnesium in the Central Nervous System. Adelaide (AU)2011. [Book]

Shmagel A, Onizuka N, Langsetmo L, et al. Low magnesium intake is associated with increased knee pain in subjects with radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2018;26(5):651-658. [Article]

Rutin

Jayachandran S, Khobre P. Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis – A Randomised Clinical Trial. J Clin Diagn Res. 2017;11(6):ZC09-ZC11. [Article]

Klein G, Kullich W, Schnitker J, Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006;24(1):25-30. [Article]

Pine Bark Extract

Cisar P, Jany R, Waczulikova I, et al. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother Res. 2008;22(8):1087-1092. [Article]

Rohdewald PJ. Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. J Med Food. 2018;21(1):1-4. [Article]

Turmeric Root Extract

Dragos D, Gilca M, Gaman L, et al. Phytomedicine in Joint Disorders. Nutrients. 2017;9(1). [Article]

Kulkarni RR, Patki PS, Jog VP, Gandage SG, Patwardhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. J Ethnopharmacol. 1991;33(1-2):91-95. [Article]

Kizhakkedath R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep. 2013;8(5):1542-1548. [Article]

Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. [Article]

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