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Formulated by physicians from
Harvard, Cornell, MIT and Bastyr

Cardiovascular Support

Healthy blood clotting is crucial for maintaining healthy circulation and cardiovascular health. Conditions that increase your risk for dangerous blood clots include smoking, sedentary lifestyle, diabetes, obesity, family history of blood clots, cardiovascular disease, cancer and flying on airplanes. Blood clots account for 80% of strokes because they impede circulation of blood and nutrients to the brain anywhere in the body where they might become a problem. Blood clots in the back of the legs is called deep vein thrombosis, and can be extremely painful. If the blood clots dislodge and begin circulating through the blood stream, they can travel to the lungs. If that happens it’s called a pulmonary embolus.

NattoPine® contains pine bark extract (300 mg per serving) and nattokinase (3650 fibrinolytic units). In a clinical trial,  pine bark extract plus nattokinase promoted healthy blood clotting and circulation. None of the participants taking nattokinase and pine bark extract had blood clots form that could cause a dangerous deep vein thrombosis, while 7.6% of people not taking the nutrient combination had potentially dangerous blood clots form. In other words, 100% of people taking the nutrients  maintained healthy circulation. And compared to those not taking the nutrients, people taking nattokinase and pine bark extract had a 27% decrease in leg swelling (edema). As a dietary supplement, pine bark extract and nattokinase support healthy blood flow and circulation.

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Highest dose nattokinase and pine bark product on the market
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Highest dose nattokinase and pine bark product on the market
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3650 fibrinolytic units nattokinase and 300 mg pine bark extract
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3650 fibrinolytic units nattokinase and 300 mg pine bark extract
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Promotes healthy blood clotting and circulation
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Promotes healthy blood clotting and circulation

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Why NattoPine Dissolves the Competition

*Footnotes

**Nattokinase is an extract from a Natto, a Japanese food from fermented soybeans. Nattokinase promotes healthy blood clotting and circulation.*

FU (fibrinolytic units) indicates the blood-clot dissolving strength of nattokinase.

††Pine bark extract contains powerful antioxidants that promote healthy circulation and quench free radicals that can damage blood vessels.*

Results based on a published human clinical trial (Angiology.2003;54(5):531-539). These doses of nattokinase and pine bark extract reduced blood clot formation that could cause deep vein thrombosis and leg swelling. In the clinical trial, nearly 10% of people who didn’t take the nattokinase and pine bark extract combination experienced a blood clot versus none of those taking the dietary supplement. In other words, the combination of nattokinase and pine bark extract promoted healthy blood clotting and circulation in 100% of people who took the nutrients. Those taking nattokinase and pine bark extract also had a 27% decrease in leg swelling (edema).*

*These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

Top Five Reasons to Take Pine Bark Extract

Top Five Reasons to Take Pine Bark Extract

Article at-a-glance: Pine bark benefits the entire vascular system and has been shown to promote healthy blood pressure and improve blood flow. A review of 24 different studies looking at nearly 1600 individuals found that pine bark promoted healthy systolic and...

Top Reasons to Take Nattokinase

Top Reasons to Take Nattokinase

Article at-a-glance: Nattokinase, an enzyme derived from the Japanese food natto, is a powerful support for optimal blood flow Nattokinase has been shown to mimic and enhance the activity of our own natural clot-dissolving enzyme, plasmin Optimal, healthy blood...

Top Tips for Improving Blood Viscosity

Top Tips for Improving Blood Viscosity

Article at-a-glance: Blood viscosity is linked to high blood pressure to autoimmune illnesses, cardiovascular disease, stroke, diabetes, depression and even cancer. Many doctors don’t think of blood viscosity when evaluating patients. It’s likely that many Americans...

Research Citations

Nattokinase and Pine Bark Extract Citations
  1. Arcangeli P. Fitoterapia. Jun 2000;71(3):236-244.
  2. Cesarone MR, Belcaro G, Nicolaides AN, et al. Angiology. Sep-Oct 2003;54(5):531-539.
  3. Devaraj S, Vega-Lopez S, Kaul N, et al. Lipids. Oct 2002;37(10):931-934.
  4. Grimm T, Skrabala R, Chovanova Z, et al. BMC Clinical Pharmacology. 2006;6(1):4.
  5. Koch R. Phytother Res. March 2002;Suppl 1:S1-5.
  6. Liu X, Wei J, Tan F, Zhou S, et al. Life Sci. Nov 8 2004;75(21):2505-2513.
  7. Ni Z, Mu Y, Gulati O. Phytother Res. Sep 2002;16(6):567-571.
  8. Packer L, Rimbach G, Virgili F. Free Radic Biol Med. Sep 1999;27(5-6):704-724.
  9. Pais E, Alexy T, Holsworth RE, Jr., et al. Clin Hemorheol Microcirc. 2006;35(1-2):139-142.
  10. Petrassi C, Mastromarino A, Spartera C. Phytomedicine. Oct 2000;7(5):383-388.
  11. Rimbach G, Virgili F, Park YC, et al. Redox Rep. 1999;4(4):171-177.
  12. Rohdewald P. Int J Clin Pharmacol Ther. Apr 2002;40(4):158-168.
  13. Tai M-W, Sweet BV. Am J Health Syst Pharm. 2006;63(12):1121-1123.
  14. Urano T, Ihara H, Umemura K, et al. J Biol Chem. Jul 6 2001;276(27):24690-24696.
  15. Young Gon Kim HYP. Phytotherapy Research. 2004;18(11):900-905.

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